Associate Professor at University of California, Los Angeles
Dr. Huiying Li is an Associate Professor in the Department of Molecular & Medical Pharmacology at University of California, Los Angeles. Dr. Li’s research focuses on the role of the skin microbiome in health and disease, including two most common skin diseases, acne vulgaris and atopic dermatitis.
By using a systems biology approach involving genomics, metagenomics, bioinformatics, microbiology, and biochemistry, Dr. Li and her group investigate the genomes, metagenomes, metatranscriptomes, and metabolomes of the microorganisms in the human microbiome and their interactions with the host. The findings from these studies can potentially lead to new diagnostics and interventions for skin diseases.
Case Study: Dissecting the human skin microbiome in health and disease
- Strain-level analysis of the skin microbiome is essential in understanding health and disease.
- Using 16S rRNA sequencing and metagenomic shotgun analysis, we compared the skin microbiome at the strain level between healthy skin and acne vulgaris, one of the most common skin diseases.
- Transcriptional activities, metabolic activities, and host immune responses are distinct among different strains of skin bacteria in health and acne.